Monosaccharides and the VO(IV) metal ion: Equilibrium, thermal studies and hypoglycemic effect

Protonation and complexation equilibriums of monosaccharides and the VO(IV) metal ion in aqueous solution as well as their effect on the hyperglycemia of diabetic rats were carried out. The mononuclear species formed by HGlu and VO2+ were confirmed by EPR. The spectra showed 8 lines (I = 7/2) characteristic of mononuclear VO-hexoses. A binuclear species was detected in small quantities, which was formed by coordination of two HGlu molecules and two VO2+ ions through a hydroxide bridge.