کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1340488 | 979737 | 2008 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Oxovanadium(IV) and (V) complexes of acetylpyridine-derived semicarbazones exhibit insulin-like activity Oxovanadium(IV) and (V) complexes of acetylpyridine-derived semicarbazones exhibit insulin-like activity](/preview/png/1340488.png)
Reaction of 2-acetylpyridine semicarbazone (H2APS), 3-acetylpyridine semicarbazone (H3APS) and 4-acetylpyridine semicarbazone (H4APS) with [VO(acac)2] (acac = acetylacetonate) gave [VO(H2APS)(acac)2] (1), [VO(H3APS)(acac)2] (2) and [VO(4APS)(acac)(H2O)] · 1/2H2O (3). Oxidation of complex 1 in acetonitrile gave [VO2(2APS)] (4). The crystal structures of complexes 1 and 4 have been determined. Complexes 1–3 were able to enhance glucose uptake and to inhibit glycerol release from adipocytes, which indicate their potential to act as insulin-mimics.
Reaction of 2-acetylpyridine (H2APS), 3-acetylpyridine (H3APS) and 4-acetylpyridine semicarbazone (H4APS) with [VO(acac)2] (acac = acetylacetonate) gave [VO(H2APS)(acac)2] (1), [VO(H3APS)(acac)2] (2) and [VO(4APS)(acac)(H2O)] · 1/2H2O (3). Oxidation of complex 1 gave [VO2(2APS)] (4). Complexes 1–3 were able to enhance glucose uptake and inhibit glycerol release from adipocytes.Figure optionsDownload as PowerPoint slide
Journal: Polyhedron - Volume 27, Issue 6, 25 April 2008, Pages 1787–1794