Identification of amino acid appended acridines as potential leads to anti-cancer drugs

In order to develop the amino acid appended acridines as potential leads for anticancer drugs, they were subjected to preliminary investigations. Screening through MTT assay as well as the phase contrast micrographs and Confocal images of immunostained C6 Glioma cells for markers such as α-tubulin, GFAP, mortalin and HSP-70 cells indicated that the compounds possess significant antiproliferative activity. The compounds also arrested cells in G0/G1 phase of the cell cycle as indicated by flow cytometry results. Moreover, the upregulation of the senescence markers such as mortalin and HSP70 in the presence of compounds 8, 9 and 12 indicate their senescence inducing potential.

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