کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1358900 981371 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pyridine hydroxamic acids are specific anti-HCV agents affecting HDAC6
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Pyridine hydroxamic acids are specific anti-HCV agents affecting HDAC6
چکیده انگلیسی

Recently we reported benzohydroxamic acids (BHAs) as potent and selective inhibitors of hepatitis C virus (HCV) replicon propagation. In this work 12 pyridine hydroxamic acids (PHAs) were synthesized and tested in full-genome replicon assay. It was found that PHAs possessed very similar anti-HCV properties compared to BHAs. Both classes of hydroxamic acids caused hyperacetylation of α-tubulin pointing to inhibition of histone deacetylase 6 (HDAC6) as part of their antiviral activity. The tested compounds did not inhibit the growth of poliovirus, displaying high selectivity against HCV.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 25, Issue 11, 1 June 2015, Pages 2382–2385
نویسندگان
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