کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1359373 | 981401 | 2014 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
6-Hydroxyquinolinium salts differing in the length of alkyl side-chain: Synthesis and antimicrobial activity
ترجمه فارسی عنوان
نمک های 6-هیدروکسیوینولینیم که در طول زنجیره آلکالین متفاوت هستند: سنتز و فعالیت ضد میکروبی
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
Quaternary ammonium salts substituted with a long alkyl chain exemplify a trustworthy group of medicinal compounds frequently employed as antifungal and antibacterial agents. A great asset of these surfactants underlying their widespread use is low local and system toxicity in humans. In this Letter, a series of novel quaternary 6-hydroxyquinolinium salts with varying length of N-alkyl chain (from C10 to C18) was synthesized and tested for in vitro activity against pathogenic bacterial and fungal strains. 6-Hydroxyquinolinium salt with C12 alkyl chain seems to be very interesting candidate due to a high antimicrobial efficacy and cytotoxic safety.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 24, Issue 22, 15 November 2014, Pages 5238–5241
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 24, Issue 22, 15 November 2014, Pages 5238–5241
نویسندگان
David Malinak, Rafael Dolezal, Jan Marek, Sarka Salajkova, Ondrej Soukup, Marcela Vejsova, Jan Korabecny, Jan Honegr, Marek Penhaker, Kamil Musilek, Kamil Kuca,