کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1359530 | 981406 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Characterization and biological evaluation of six new dimeric lignans with an unusual α,β-unsaturated ketone motif from Zanthoxylum simulans
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Investigation of the bark of Zanthoxylum simulans afforded six new dimeric lignans zanthpodocarpins C–H (1–6) bearing an unusual α,β-unsaturated ketone group. The new structures of 1–6 were determined by using detailed spectroscopic analysis. All of the isolated compounds were examined for their inhibitory effects against rat joint synovial cell and splenocyte proliferation. Compounds 1–6 showed potent anti-inflammatory activities with IC50 values ranging from 18.6 to 36.1 μM, and 13.8 to 74.3 μM.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 24, Issue 19, 1 October 2014, Pages 4667–4671
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 24, Issue 19, 1 October 2014, Pages 4667–4671
نویسندگان
Jun-Feng Wang, Yi-Hui Deng, Sheng-Hui Yang, Yan-Qun Liu, Yue-Hu Wang, Wei-Wei Pan, Xiao-Jiang Zhou,