کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1361267 981460 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fluorescent nucleosides with ‘on–off’ switching function, pH-responsive fluorescent uridine derivatives
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Fluorescent nucleosides with ‘on–off’ switching function, pH-responsive fluorescent uridine derivatives
چکیده انگلیسی

We synthesized various pH-responsive fluorescent deoxyuridine derivatives (1a–g). These fluorescent nucleosides exhibited distinctive fluorescence at 470–600 nm in aqueous solvents containing methanol only at acidic to neutral pH values. In particular, 1f exhibited strong fluorescence only at pH range of 3.1–7.2 with a pKa of 6.1. Such pH-sensitive fluorescent nucleosides can be used as ‘on–off’ fluorescence switch for monitoring pH change in biological systems, particularly for cancer cell detection.

Structures of fluorescent pH responsive nucleosides.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 8, 15 April 2012, Pages 2753–2756
نویسندگان
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