کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1361319 981460 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Discovery of novel P3-oxo inhibitor of hepatitis C virus NS3/4A serine protease
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Discovery of novel P3-oxo inhibitor of hepatitis C virus NS3/4A serine protease
چکیده انگلیسی

A novel series of P3 oxo-modified macrocyclic hepatitis C virus NS3/4A serine protease inhibitor was designed, synthesized and biologically evaluated. The hydroxy-substituted inhibitor 10 demonstrated high potency in genotype 1a and 1b replicon and in the panel of HCV protease mutants. Interestingly, the t-butyl carbonate analog 9c, while not the most potent one in this series, exhibited a virtually flat potency profile in the panel of HCV protease mutants, thus providing opportunity for further optimization.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 8, 15 April 2012, Pages 2993–2996
نویسندگان
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