کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1361503 981465 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury
چکیده انگلیسی

In this Letter we describe the optimization of an aminopurine lead (1) with modest potency and poor overall kinase selectivity which led to the identification of a series of potent, selective JNK inhibitors. Improvement in kinase selectivity was enabled by introduction of an aliphatic side chain at the C-2 position. CC-359 (2) was selected as a potential clinical candidate for diseases manifested by ischemia reperfusion injury.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 3, 1 February 2012, Pages 1427–1432
نویسندگان
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