Psilostachyin, acetylated pseudoguaianolides and their analogues: Preparation and evaluation of their anti-inflammatory potential

Naturally occurring acetylated pseudoguaianolides and psilostachyin including their analogues were synthesized. The structure of semi-synthetic psilostachyin was also confirmed by X-ray crystallography. The anti-inflammatory potential of all the derivatives has been evaluated through in vitro expression of TNF-α, IL-1β and IL-6 in murine neutrophils.

Naturally occurring acetylated pseudoguaianolides and spirolactone psilostachyin including their analogues were synthesized and evaluated for their anti-inflammatory potential.Figure optionsDownload as PowerPoint slide