کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1361962 | 981475 | 2011 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis and in vitro antitumor activity of new butenolide-containing dithiocarbamates Synthesis and in vitro antitumor activity of new butenolide-containing dithiocarbamates](/preview/png/1361962.png)
Three series of butenolide-containing dithiocarbamates were designed and synthesized. Their anti-tumor activity in vitro was evaluated. Among them compound I-14 exhibited broad spectrum anti-cancer activity against five human cancer cell lines with IC50 <30 μM. Structure–activity relationship analysis showed that the introduction of dithiocarbamate side chains on the C-3 position of butenolide was crucial for anti-tumor activity.
Three series of butenolide-containing dithiocarbamates were designed and synthesized. Their anti-tumor activity in vitro was evaluated. Among them compound I-14 exhibited excellent anti-cancer activity against five human cancer cell lines with IC50 <10 μg/mL. Structure–activity relationship analysis showed that the introduction of dithiocarbamate side chains on the C-3 position of butenolide was crucial for anti-tumor activity.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 10, 15 May 2011, Pages 3074–3077