کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1361964 | 981475 | 2011 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Regioselective one pot synthesis of 3,3′-diindolylethylene derivatives and study of their cytotoxic activity
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Regioselective one pot synthesis of 3,3′-diindolylethylene derivatives and study of their cytotoxic activity Regioselective one pot synthesis of 3,3′-diindolylethylene derivatives and study of their cytotoxic activity](/preview/png/1361964.png)
چکیده انگلیسی
2,2′-Diphenyl-3,3′-diindolylethylene (DPDIE) derivatives 3a–g were regioselectively prepared in one pot from indoles 1a–g in the presence of Lewis acids and were subsequently evaluated for cytotoxic activity against human leukemic cell lines, U937 and K562. The most potent compound 3g exhibited IC50 of 13.0–17.0 μM.
Synthesis and study of cytotoxic activity of 2,2′-diphenyl-3,3′-diindolylethylene derivatives are reported.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 10, 15 May 2011, Pages 3084–3087
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 10, 15 May 2011, Pages 3084–3087
نویسندگان
Madhumita Mandal, Deepak Kumar, Rajneeta Roy, Rupashree Sen, Padma Das, Mitali Chatterjee, Parasuraman Jaisankar,