Simultaneous DSC-FTIR microspectroscopy used to screen and detect the co-crystal formation in real time

We first report that the formation of pharmaceutical co-crystal can be synchronously screened and confirmed by a simultaneous DSC-FTIR microspectroscopic system, in which this combined unique system giving spectroscopic and thermodynamic information could provide a easy and direct way for one step screening and qualitative detection of the co-crystal formation in real time.

Thermal-dependent three-dimensional FTIR spectral plot of the physical mixture of IMC/SAC and its temperature-dependent changes in peak intensity of the specified IR bands.Figure optionsDownload as PowerPoint slide