کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1362189 | 981480 | 2011 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase](/preview/png/1362189.png)
چکیده انگلیسی
The synthesis and inhibitory potencies of a novel series of β-amino alcohols, based on the hit-compound 3-[3′-(4″-cyclopent-2‴-en-1‴-ylphenoxy)-2′-hydroxypropyl]-5,5 dimethylimidazolidine-2,4-dione as specific inhibitors of mycobacterial N-acetyltransferase (NAT) enzymes are reported. Effects of synthesised compounds on growth of Mycobacterium tuberculosis have been determined.
The synthesis and in vitro characterisation of a novel series of β-amino alcohol compounds based upon the hit compound identified from a screening program 3-[3′-(4″-cyclopent-2‴-en-1‴-ylphenoxy)-2′-hydroxypropyl]-5,5-dimethylimidazolidine-2,4-dione against prokaryotic arylamine N-acetyltransferase enzymes are reported.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 4, 15 February 2011, Pages 1185–1190
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 4, 15 February 2011, Pages 1185–1190
نویسندگان
Elizabeth Fullam, Areej Abuhammad, David L. Wilson, Matthew C. Anderton, Steve G. Davies, Angela J. Russell, Edith Sim,