Synthesis, biological evaluation and radiolabelling by 18F-fluoroarylation of a dopamine D3-selective ligand as prospective imaging probe for PET

Radical 18F-fluoroarylation with fluorine-18-labelled arenediazonium chlorides has been successfully applied to the radiochemical synthesis of the dopamine D3-selective ligand SH 317 ([18F]8). SH 317 has been evaluated as a new PET ligand candidate by in vivo experiments.

Radical 18F-fluoroarylation with fluorine-18-labelled arenediazonium chlorides has been successfully applied to the radiochemical synthesis of the dopamine D3-selective ligand SH 317 ([18F]8). SH 317 has been evaluated as a new PET ligand candidate by in vivo experiments.Figure optionsDownload as PowerPoint slide