5-Benzyloxytryptamine as an antagonist of TRPM8

5-Benzyloxytryptamine 19 was found to act as an antagonist of the TRPM8 ion-channel. For example, 19 had an IC50 of 0.34 μM when menthol was used as the stimulating agonist. Related commercially-available tryptamine derivatives showed diminished, or no antagonist activity at TRPM8. The structural similarity of 5-benzyloxytryptamine to other literature TRPM8 antagonists was noted.

5-Benzyloxytryptamine 19 was found to be an antagonist of TRPM8. Related tryptamine derivatives showed diminished, or no activity at TRPM8.Figure optionsDownload as PowerPoint slide