کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1362564 981490 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cholesterol-derived novel anti-apoptotic agents on the structural basis of ginsenoside Rk1
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Cholesterol-derived novel anti-apoptotic agents on the structural basis of ginsenoside Rk1
چکیده انگلیسی

Design and synthesis of cholesterol-derived anti-apoptotic agents were described. The synthesized cholesterol analogs designed on the structural basis of ginsenoside Rk1 inhibited the undesirable apoptosis of human endothelial cells, which are induced by a vascular injury. In particular, analogue 1 possessing 4,6-di-O-acetyl-2,3-dideoxyhex-2-enopyran linked to hydroxyl group of cholesterol exhibited the most effective anti-apoptotic activities at both 5 and 10 μg/ml.

Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 23, 1 December 2010, Pages 7102–7105
نویسندگان
, , , , , , ,