کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1362567 | 981490 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
N-Substituted pyrrolidines and tetrahydrofurans as novel AMPAR positive modulators
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: N-Substituted pyrrolidines and tetrahydrofurans as novel AMPAR positive modulators N-Substituted pyrrolidines and tetrahydrofurans as novel AMPAR positive modulators](/preview/png/1362567.png)
چکیده انگلیسی
A series of novel AMPA receptor positive modulators displaying CNS penetration have been discovered with sub-micromolar activity and good selectivity over the cardiac channel receptor, hERG. We describe here the synthesis of these compounds which are biaryl pyrrolidine and tetrahydrofuran sulfonamides and disclose their activities against the human GluA2 flip isoform homotetrameric receptor.
This work describes the synthesis and biological activity of a series of pyrrolidine and tetrahydrofuran analogues as AMPA receptor positive modulators. Ar = substituted phenyl or heterocycle.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 23, 1 December 2010, Pages 7116–7119
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 23, 1 December 2010, Pages 7116–7119
نویسندگان
Kevin M. Thewlis, Laura Aldegheri, Mark H. Harries, Claudette Mookherjee, Beatrice Oliosi, Simon E. Ward,