Search for influence of spatial properties on affinity at α1-adrenoceptor subtypes for phenylpiperazine derivatives of phenytoin

Antagonist properties at α1-adrenoceptor subtypes, A, B and D for 1-[2-hydroxy-3-(4-phenylpiperazin-1-yl)-propyl]-2,4-dioxo-5,5-diphenylimidazolidine derivatives were evaluated in functional bioassays. Bremner's pharmacophores based SAR-studies were carried out.