Design, synthesis, and anticancer activities of novel perfluoroalkyltriazole-appended 2′-deoxyuridines

We have focused on the C5-modification of 2′-deoxyuridine with substituted heterocycles for bioactivity, such as antiviral or anticancer activity. Herein, we report a novel class of nucleoside analogues with perfluoroalkyltriazole moiety as an anticancer drug candidate.

Novel synthesized perfluoroalkyltriazole-appended nucleosides exhibit anticancer activities against several cancer cell lines.Figure optionsDownload as PowerPoint slide