Discovery of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as selective antagonists of the kappa opioid receptor. Part 1

Discovery and SAR studies of a novel series of potent and selective kappa opioid receptor antagonists containing an 8-azabicylo[3.2.1]octane core is described. Analog 6c was shown to successfully inhibit kappa agonist-induced rat diuresis in vivo.