New anti-malarial phenylpropanoid conjugated iridoids from Morinda morindoides

A new phenylpropanoid conjugated iridoid together with four known congeners was isolated from Morinda morindoides, used for the therapy of malaria traditionally in some African countries, as anti-malarial principles through bioassay-guided separation. Furthermore, their absolute stereostructures were unambiguously established by a combination of modified Mosher’s method and chemical correlation.

A new phenylpropanoid conjugated iridoid (1) together with four known congeners (2–5) was isolated from the leaves of Morinda morindoides as potent anti-malarial principles through bioassay-guided separation.Figure optionsDownload as PowerPoint slide