کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1363692 | 981520 | 2009 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: In vivo evaluation of diaminodiphenyls: Anticonvulsant agents with minimal acute neurotoxicity In vivo evaluation of diaminodiphenyls: Anticonvulsant agents with minimal acute neurotoxicity](/preview/png/1363692.png)
Several diaminodiphenyl analogs were assessed in vivo for their capacity to inhibit seizure induction and propagation in rodents. Both 3,4′- and 4,4′-diaminodiphenyl compounds prevented seizures for as long as 4 h after maximal electric shock induction. 4,4′-Diphenyl compounds bridged by a methylene, sulfide, or carbonyl linker also attenuated focal seizure acquisition in a kindling model. Of these analogs, based upon data generated in two rodent species, 4,4′-thiodianiline (1) was identified as the most active compound, significantly reducing seizure staging scores and after-discharge duration for several hours after systemic administration. All compounds were devoid of acute in vivo neurotoxicity at doses well above those required for anticonvulsant activity.
Diaminodiphenyl compounds 1–6 exert in vivo anticonvulsant activity with minimal acute neurotoxicity.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 17, 1 September 2009, Pages 5012–5015