کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1363726 981520 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
2-Aminobenzimidazoles as potent Aurora kinase inhibitors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
2-Aminobenzimidazoles as potent Aurora kinase inhibitors
چکیده انگلیسی
This Letter describes the discovery and key structure-activity relationship (SAR) of a series of 2-aminobenzimidazoles as potent Aurora kinase inhibitors. 2-Aminobenzimidazole serves as a bioisostere of the biaryl urea residue of SNS-314 (1c), which is a potent Aurora kinase inhibitor and entered clinical testing in patients with solid tumors. Compared to SNS-314, this series of compounds offers better aqueous solubility while retaining comparable in vitro potency in biochemical and cell-based assays; in particular, 6m has also demonstrated a comparable mouse iv PK profile to SNS-314.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 17, 1 September 2009, Pages 5158-5161
نویسندگان
, , , , , , , , , , , , , , , ,