کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1363727 981520 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Metallo-β-lactamase inhibitory activity of phthalic acid derivatives
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Metallo-β-lactamase inhibitory activity of phthalic acid derivatives
چکیده انگلیسی

4-Butyl-3-methylphthalic acid was recognized as a metallo-β-lactamase inhibitor. The structure–activity relationship study of substituted phthalic acids afforded 3-phenylphthalic acid derivatives as potent IMP-1 inhibitors. On the other hand, 3-substituted with 4-hydroxyphenyl phthalic acid derivative displayed a potent combination effect with biapenem (BIPM) against Pseudomonas aeruginosa that produce IMP-1.

3-Substituted phthalic acid derivatives showed potent IMP-1 inhibitory activity, moreover these compounds have combination effect with Biapenem against Pseudomonas aeruginosa that produces IMP-1.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 17, 1 September 2009, Pages 5162–5165
نویسندگان
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