کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1363732 | 981520 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Discovery of novel phenethylpyridone derivatives as potent melanin-concentrating hormone 1 receptor antagonists
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Discovery of novel phenethylpyridone derivatives as potent melanin-concentrating hormone 1 receptor antagonists Discovery of novel phenethylpyridone derivatives as potent melanin-concentrating hormone 1 receptor antagonists](/preview/png/1363732.png)
چکیده انگلیسی
Novel phenethylpyridone derivatives were identified as potent human melanin-concentrating hormone 1 receptor (MCH-1R) antagonists. A search for surrogates for the 4-(2-aminoethoxy)phenyl moiety of 1 resulted in discovery of 2-[4-(aminomethyl)phenyl]ethyl substructure as in 6a. Successive optimization of the right-hand moiety led to the identification of a number of potent derivatives.
A series of phenethylpyridones was identified as a potent melanin-concentrating hormone 1 receptor antagonist. The synthesis and structure–activity relationships (SAR) are described.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 17, 1 September 2009, Pages 5186–5190
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 17, 1 September 2009, Pages 5186–5190
نویسندگان
Makoto Ando, Etsuko Sekino, Yuji Haga, Minoru Moriya, Masahiko Ito, Junko Ito, Hisashi Iwaasa, Akane Ishihara, Akio Kanatani, Norikazu Ohtake,