کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1363735 | 981520 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Imidazo-pyrazine derivatives as potent CXCR3 antagonists
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
A general way of improving the potency of CXCR3 antagonists with fused hetero-bicyclic cores was identified. Optimization efforts led to the discovery of a series of imidazo-pyrazine derivatives with improved pharmacokinetic properties in addition to increased potency. The efficacy of the lead compound 21 is evaluated in a mouse lung inflammation model.
A general way of improving the potency of CXCR3 antagonists with fused hetero-bicyclic cores was identified. This led to the discovery of a series of imidazo-pyrazine derivatives with improved pharmacokinetics. Compound 21 was evaluated in a lung inflammation model.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 17, 1 September 2009, Pages 5200–5204
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 17, 1 September 2009, Pages 5200–5204
نویسندگان
Xiaohui Du, Darin J. Gustin, Xiaoqi Chen, Jason Duquette, Lawrence R. McGee, Zhulun Wang, Karen Ebsworth, Kirk Henne, Bryan Lemon, Ji Ma, Shichang Miao, Emmanuel Sabalan, Timothy J. Sullivan, George Tonn, Tassie L. Collins, Julio C. Medina,