کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1363735 981520 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Imidazo-pyrazine derivatives as potent CXCR3 antagonists
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Imidazo-pyrazine derivatives as potent CXCR3 antagonists
چکیده انگلیسی

A general way of improving the potency of CXCR3 antagonists with fused hetero-bicyclic cores was identified. Optimization efforts led to the discovery of a series of imidazo-pyrazine derivatives with improved pharmacokinetic properties in addition to increased potency. The efficacy of the lead compound 21 is evaluated in a mouse lung inflammation model.

A general way of improving the potency of CXCR3 antagonists with fused hetero-bicyclic cores was identified. This led to the discovery of a series of imidazo-pyrazine derivatives with improved pharmacokinetics. Compound 21 was evaluated in a lung inflammation model.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 17, 1 September 2009, Pages 5200–5204
نویسندگان
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