کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1363747 981520 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Discovery of a small molecule inhibitor through interference with the gp120–CD4 interaction
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Discovery of a small molecule inhibitor through interference with the gp120–CD4 interaction
چکیده انگلیسی

A series of piperazine derivatives were designed and synthesised as gp120–CD4 inhibitors. SAR studies led to the discovery of potent inhibitors in a cell based anti viral assay represented by compounds 9 and 28. The rat pharmacokinetic and antiviral profiles of selected compounds are also presented.

Identification and SAR of a series of piperazine derivatives as inhibitors of the gp120–CD4 interaction is described.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 17, 1 September 2009, Pages 5246–5249
نویسندگان
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