کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1363947 | 981525 | 2009 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis of a new opioid ligand having the oxabicyclo[3.2.1]octane skeleton using a new rearrangement reaction Synthesis of a new opioid ligand having the oxabicyclo[3.2.1]octane skeleton using a new rearrangement reaction](/preview/png/1363947.png)
An attempt to prepare a trimer having the 1,3,5-trioxazatriquinane skeleton led to discovery of a novel rearrangement reaction that afforded a compound with an oxabicyclo[3.2.1]octane skeleton whose reaction mechanism was proposed. On the basis of this mechanism, we synthesized the rearranged product from a dimethyl acetal intermediate in excellent yield. The compound with an oxabicyclo[3.2.1]octane skeleton showed high affinity for μ and κ but not δ opioid receptor types. The compound expected to be a key intermediate for novel κ selective ligands.
Novel morphinan derivative having oxabicyclo[3.2.1]octane skeleton was prepared from dimethyl acetal derivative. The novel compound showed strong affinity for μ and κ opioid receptor types.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 9, 1 May 2009, Pages 2416–2419