کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1363973 981525 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The discovery of potent, selective, and orally bioavailable PDE9 inhibitors as potential hypoglycemic agents
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
The discovery of potent, selective, and orally bioavailable PDE9 inhibitors as potential hypoglycemic agents
چکیده انگلیسی

Starting from a non-selective pyrazolo-pyrimidone lead, the sequential use of parallel medicinal chemistry and directed synthesis led to the discovery of potent, highly selective, and orally bioavailable PDE9 inhibitors. The availability of these tools allowed for a thorough evaluation of the therapeutic potential of PDE9 inhibition.

Starting from the non-selective lead 1, the sequential use of library and directed synthesis led to the optimized PDE9 inhibitor 13.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 9, 1 May 2009, Pages 2537–2541
نویسندگان
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