Exploring a pocket for polycycloaliphatic groups in the CXCR3 receptor with the aid of a modular synthetic strategy

A CXCR3 pocket capable of accommodating polycycloaliphatics was explored using a modular synthetic strategy. The systematic studies reveal that the tricyclic 2-adamantane and bicyclic (iso)bornyl group are efficiently recognized by CXCR3.

The strategic use of specific polycycloaliphatic groups in obtaining small antagonists for the CXCR3 receptor was investigated. 2-Adamantyl- and (iso)bornyl groups proved beneficial.Figure optionsDownload as PowerPoint slide