Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants

New structural classes of KV1.3 and IK-1 ion channel blockers have been identified based on a virtual high throughput screening approach using a homology model of KcsA. These compounds display inhibitory effects on T-cell and/or keratinocyte proliferation and immunosuppressant activity within a DTH animal model.

Applying vHTS based on a homology model, potent inhibitors of KV1.3 and IK-1 were identified.Figure optionsDownload as PowerPoint slide