The discovery of equipotent PPARα/γ dual activators

We report the design and synthesis of equipotent PPARα/γ dual agonists starting from selective PPAR alpha agonist 1. In vivo data for 7 in the Zucker fa/fa rat are presented.

We report the design and synthesis of equipotent PPARα/γ dual agonists starting from the selective PPARα agonist 1. In vivo data for 7 in the Zucker fa/fa rat are presented.Figure optionsDownload as PowerPoint slide