کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1364604 981540 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Catalytic site-selective synthesis and evaluation of a series of erythromycin analogs
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Catalytic site-selective synthesis and evaluation of a series of erythromycin analogs
چکیده انگلیسی

The generation of a series of analogs of erythromycin A (EryA, 2) is described. In this study, we compared two peptide-based catalysts—one originally identified from a catalyst screen (5) and its enantiomer (ent-5)—for the selective functionalization of EryA. The semi-synthetic analogs were subjected to MIC evaluation with two bacterial strains and compared to unfunctionalized EryA.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 22, 15 November 2008, Pages 6007–6011
نویسندگان
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