کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1364773 981545 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design, synthesis and structure–activity relationship of simple bis-amides as potent inhibitors of GlyT1
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Design, synthesis and structure–activity relationship of simple bis-amides as potent inhibitors of GlyT1
چکیده انگلیسی

Several novel classes of potent and small amide-type inhibitors of glycine transport (GlyT1) were developed through sequential simplification of a benzodiazepinone-lead structure identified from a high-throughput screening. The most potent compounds of these structurally simple classes show low nanomolar inhibition at the GlyT1 target.

Novel classes of potent and small bis-amide type inhibitors of GlyT1 were developed through simplification of a benzodiazepinone-lead structure identified from high-throughput screening.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 20, 15 October 2008, Pages 5533–5536
نویسندگان
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