Synthesis and biological evaluation of alkoxycoumarins as novel nematicidal constituents

We synthesized all of the monomethoxycoumarins, 5-alkoxycoumarins and their derivatives, and investigated their nematicidal activity against the phytopathogenic nematode, Bursaphelenchus xylophilus. Among the compounds, 5-ethoxycoumarin showed the highest nematicidal activity. Furthermore, 5-ethoxycoumarin was comparatively harmless against both the brine shrimps, Artemia salina, and the Japanese killifish, Oryzias latipes.

All monomethoxycoumarins and several 5-alkoxycoumarins were examined nematicidal activity and environment safety using crustacean and fish. Among them 5-alkoxycoumarins produced an excellent result even though their simple skeletons.Figure optionsDownload as PowerPoint slide