Structure, antimicrobial activity and DNA-binding properties of the cobalt(II)–sparfloxacin complex

The neutral mononuclear cobalt(II) complex with sparfloxacin has been prepared and characterized with physicochemical, spectroscopic and electrochemical techniques, and molecular mechanics calculations. The interaction of the complex with calf-thymus DNA has been investigated with UV spectroscopy, cyclic voltammetry, and competitive studies with ethidium bromide. The antimicrobial activity of the complex has been tested against three microorganisms.

The synthesis, characterization, antimicrobial activity and DNA-binding properties of the mononuclear cobalt(II) complex with the third-generation quinolone sparfloxacin are reported.Figure optionsDownload as PowerPoint slide