کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1365170 981554 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
N-Alkylated galanthamine derivatives: Potent acetylcholinesterase inhibitors from Leucojum aestivum
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
N-Alkylated galanthamine derivatives: Potent acetylcholinesterase inhibitors from Leucojum aestivum
چکیده انگلیسی

N-(14-Methylallyl)norgalanthamine, a new natural compound, together with five known alkaloids: N-allylnorgalanthamine, galanthamine, epinorgalanthamine, narwedine, and lycorine were isolated from mother liquors (waste material) obtained after industrial production of galanthamine hydrobromide from Leucojum aestivum leaves. The structures of N-allylnorgalanthamine and N-(14-methylallyl)norgalanthamine were completely determined by 1H and 13C NMR spectroscopy and two-dimensional experiments. N-allylnorgalanthamine (IC50 = 0.18 μM) and N-(14-methylallyl)norgalanthamine (IC50 = 0.16 μM) inhibit AChE considerably more than the approved drug galanthamine (IC50 = 1.82 μM).

N-Allylnorgalanthamine (1) and N-(14-methylallyl)norgalanthamine (2) inhibit AChE more than the approved drug galanthamine.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 7, 1 April 2008, Pages 2263–2266
نویسندگان
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