Solid-phase synthesis of oligomers carrying several chromophore units linked by phosphodiester backbones

A method for the preparation of oligomers by linking chromophore units is described. Specifically, the synthesis of chromophore units having a protected-hydroxyl group and a phosphoramidite function is described, along with a method to link several units using solid-phase phosphite-triester protocols.

The synthesis of oligomers having several DNA-intercalating units linked by phosphodiester bonds is reported.Figure optionsDownload as PowerPoint slide