کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1365183 | 981554 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Discovery of 2-amino-6-carboxamidobenzothiazoles as potent Lck inhibitors
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A novel series of 2-amino-6-carboxamidobenzothiazole was discovered to have potent Lck inhibitory properties. A highly efficient chemistry was developed. Also described are the detailed SAR study and the BaF3 cell line profiling for this series.
A novel series of 2-amino-6-carboxamidobenzothiazole was discovered to have potent Lck inhibitory properties. A highly efficient chemistry was developed. Many potent analogues were generated with urea, carbamate, heteroarylamine or alkylamine at the C-2 position. The SAR for the middle ring and the right side aryl group was also explored. The selectivity profile was herein included.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 7, 1 April 2008, Pages 2324–2328
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 7, 1 April 2008, Pages 2324–2328
نویسندگان
Shenlin Huang, Zuosheng Liu, Shin-Shay Tian, Mark Sandberg, Tracy A. Spalding, Russell Romeo, Maya Iskandar, Zhiliang Wang, Donald Karanewsky, Yun He,