Synthesis of barbiturate-based methionine aminopeptidase-1 inhibitors

The syntheses of a new class of barbiturate-based inhibitors for human and Escherichia Coli methionine aminopeptidase-1 (MetAP-1) are described. Some of the synthesized inhibitors show selective inhibition of the human enzyme with high potency.

The syntheses of a new class of barbiturate-based inhibitors for methionine aminopeptidase-1 are described.Figure optionsDownload as PowerPoint slide