Microwave-assisted synthesis and antimicrobial activities of flavonoid derivatives

Eleven flavonoid derivatives were synthesised using a modified Baker–Venkataraman rearrangement, and subsequent microwave-assisted closure of the heterocyclic ring. All of the synthetic compounds displayed antifungal activity against Aspergillus niger and Fusarium oxysporium, and two of the synthetic flavonoid analogues exhibited significant activity against methicillin-resistant Staphylococcus aureus.

A series of simple synthetic flavonoid derivatives were found to have significant antifungal activity. Two of the compounds also displayed antibacterial activity against methicillin-resistant Staphylococcus aureus.Figure optionsDownload as PowerPoint slide