کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1365364 981560 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and antimycobacterial evaluation of new trans-cinnamic acid hydrazide derivatives
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and antimycobacterial evaluation of new trans-cinnamic acid hydrazide derivatives
چکیده انگلیسی

In this work, we report the synthesis and the antimycobacterial evaluation of new trans-cinnamic acid derivatives of isonicotinic acid series (5) and benzoic acid series (6), designed by exploring the molecular hybridization approach between isoniazid (1) and trans-cinnamic acid derivative (3). The minimum inhibitory concentration (MIC) of the compounds 5a–d and 6c exhibited activity between 3.12 and 12.5 μg/mL and could be a good start point to find new lead compounds against multi-drug resistant tuberculosis.

The present article describes a series of ten new trans-cinnamic acid hydrazide derivatives, which were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 2, 15 January 2008, Pages 538–541
نویسندگان
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