کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1365399 981560 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
α-Hydroxy amides as a novel class of bradykinin B1 selective antagonists
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
α-Hydroxy amides as a novel class of bradykinin B1 selective antagonists
چکیده انگلیسی

Antagonism of the bradykinin B1 receptor represents a potential treatment for chronic pain and inflammation. Novel antagonists incorporating α-hydroxy amides were designed that display low-nanomolar affinity for the human bradykinin B1 receptor and good bioavailability in the rat and dog. In addition, these functionally active compounds show high passive permeability and low susceptibility to phosphoglycoprotein mediated efflux, predictive of good CNS exposure.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 2, 15 January 2008, Pages 716–720
نویسندگان
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