کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1365406 | 981560 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Calcitonin gene-related peptide (CGRP) receptor antagonists: Investigations of a pyridinone template
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In our effort to find potent, orally bioavailable CGRP receptor antagonists for the treatment of migraine, a novel series based on a pyridinone template was investigated. After optimizing the privileged structure and the placement of the attached phenyl ring, systematic SAR was carried out on both the N-alkyl and C-5 aryl substituents. Several analogs with good potency and pharmacokinetic profiles were identified.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 2, 15 January 2008, Pages 755–758
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 2, 15 January 2008, Pages 755–758
نویسندگان
Diem N. Nguyen, Daniel V. Paone, Anthony W. Shaw, Christopher S. Burgey, Scott D. Mosser, Victor Johnston, Christopher A. Salvatore, Yvonne M. Leonard, Cynthia M. Miller-Stein, Stefanie A. Kane, Kenneth S. Koblan, Joseph P. Vacca, Samuel L. Graham,