کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1365426 981560 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antitumor effects of curcumin and structurally β-diketone modified analogs on multidrug resistant cancer cells
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Antitumor effects of curcumin and structurally β-diketone modified analogs on multidrug resistant cancer cells
چکیده انگلیسی

Using concepts of bioisostery a series of curcumin analogs were synthesized: the diketonic system of the compound was elaborated into enaminones, oximes, and the isoxazole heterocycle. The cell growth inhibitory and apoptosis inducing effects of the new analogs were evaluated by in vitro assays in the hepatocellular carcinoma HA22T/VGH cells, as well as in the MCF-7 breast cancer cell line and in its multidrug resistant (MDR) variant MCF-7R. Increased antitumor activity on all cell lines was found with the isoxazole analog and especially with the benzyl oxime derivative; in the HA22T/VGH cell model, the latter compound inhibited constitutive NF-κB activation.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 2, 15 January 2008, Pages 845–849
نویسندگان
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