کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1365555 | 981564 | 2007 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
High dopamine transporter selectivity can be displayed by remarkably simple non-nitrogen containing inhibitors
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: High dopamine transporter selectivity can be displayed by remarkably simple non-nitrogen containing inhibitors High dopamine transporter selectivity can be displayed by remarkably simple non-nitrogen containing inhibitors](/preview/png/1365555.png)
چکیده انگلیسی
A series of 2-(3,4-dichlorophenyl)-cyclopent-1-enyl carboxylic acid esters and amides were prepared and tested for binding to the DAT, SERT, and NET. The achiral compounds were easily attained and found to inhibit DAT binding with Ki-values ranging from 0.095 to 0.00003 mM. Among the compounds tested 2-(3,4-dichlorophenyl)-cyclopent-1-enyl carboxylic acid 2-methylphenyl ester was found to be highly selective with SERT/DAT > 7000; NET/DAT > 1700, Ki = 60 nM.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 21, 1 November 2007, Pages 6019–6025
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 21, 1 November 2007, Pages 6019–6025
نویسندگان
Søren V. Boye, Fernando Ortega-Caballero, Steffen Sinning, Ove Wiborg, Henrik H. Jensen, Mikael Bols,