Synthesis of the A,B-ring-truncated OSW saponin analogs and their antitumor activities

The A,B-ring-truncated OSW saponin analogs (1, 18a, and 18b) were synthesized. These greatly simplified trans-hydrindane disaccharides retained considerable inhibitory activity against the growth of HeLa and Jurkat T cells (IC50 = 0.8–21.1 μM).

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