کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1365862 981575 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structure–activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 1
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Structure–activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 1
چکیده انگلیسی

A structurally unique and new class of opioid receptor antagonists (OpRAs) that bear no structural resemblance with morphine or endogenous opioid peptides has been discovered. A series of carboxamido-biaryl ethers were identified as potent receptor antagonists against mu, kappa and delta opioid receptors. The structure–activity relationship indicated para-substituted aryloxyaryl primary carboxamide bearing an amine tether on the distal phenyl ring was optimal for potent in vitro functional antagonism against three opioid receptor subtypes.

A structurally unique and new class of opioid receptor antagonists (OpRAs) that bear no structural resemblance with morphine or endogenous opioid peptides has been discovered. A series of carboxamido-biaryl ethers were identified as potent receptor antagonists against mu, kappa, and delta opioid receptors.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 19, 1 October 2007, Pages 5349–5352
نویسندگان
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