کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1366199 | 981585 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and in vitro protozoocidal activity of diazabicyclic benzotropolone derivatives
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and in vitro protozoocidal activity of diazabicyclic benzotropolone derivatives Synthesis and in vitro protozoocidal activity of diazabicyclic benzotropolone derivatives](/preview/png/1366199.png)
چکیده انگلیسی
We describe the synthesis and protozoocidal evaluation of a series of diazabicycles based on benzotropolone ethers. Several of the compounds, which can be obtained through a high-yielding hetero Diels–Alder reaction using simple and readily available starting materials, have in vitro activities against Trypanosoma cruzi and Leishmania donovani that are comparable to, and in some cases better than, those of currently used chemotherapies.
The synthesis and protozoocidal evaluation of a series of endocyclic hydrazines based on benzotropolone ethers is described.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 15, 1 August 2007, Pages 4183–4186
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 15, 1 August 2007, Pages 4183–4186
نویسندگان
Alexander Khrizman, Jason S. Moulthrop, Susan Little, Hayley Wharton, Vanessa Yardley, Guillermo Moyna,